Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs. Issue 4 (29th November 2018)

• Record Type: Journal Article
• Authors: ter Meer, Marja; Dillion, Ross; Nielsen, Signe Maria; Walther, Raoul; Meyer, Rikke L.; Daamen, Willeke F.; van den Heuvel, Lambertus P.; van der Vliet, J. Adam; Lomme, Roger M. L. M.; Hoogeveen, Yvonne L.; Schultze Kool, Leo J.; Schaffer, Jeremy E.; Zelikin, Alexander N.
• Is Part Of: Chemical communications. Volume 55:Issue 4(2019)
• Page Start: 443
• Page End: 446
• Publication Date: 2018-11-29
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc08737g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The unexpected discovery presented herein is that industrialized metallic wires can perform conversion of the glucuronide prodrugs with ensuing antibacterial effects. Abstract : Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.