A novel thermo-responsive multiblock architecture composed of a sequential peptide and an amino acid-derived vinyl polymer: toward protein-mimicking single-chain folding. Issue 10 (16th January 2019)

• Record Type: Journal Article
• Authors: Nishimura, Shin-nosuke; Higashi, Nobuyuki; Koga, Tomoyuki
• Is Part Of: Chemical communications. Volume 55:Issue 10(2019)
• Page Start: 1498
• Page End: 1501
• Publication Date: 2019-01-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc09051c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel multiblock hybrid copolymer composed of a β-sheet peptide and a glycine-derived vinyl polymer was developed to achieve single-chain folding into well-defined nanoparticles. Abstract : A novel multiblock architecture composed of an alternating β-sheet forming oligopeptide and a thermo-responsive glycine-derived vinyl polymer was synthesized. The polymer exhibited lower critical solution temperature (LCST) behavior in water, unlike the behavior of a glycine-derived homopolymer, and formed nanoparticles through protein-mimicking folding driven by thermal cycle-induced β-sheet formation.