A peptide-based four-color fluorescent polydopamine nanoprobe for multiplexed sensing and imaging of proteases in living cells. Issue 11 (18th January 2019)

• Record Type: Journal Article
• Authors: Xu, Jiayao; Fang, Lina; Shi, Ming; Huang, Yong; Yao, Lifang; Zhao, Shulin; Zhang, Liangliang; Liang, Hong
• Is Part Of: Chemical communications. Volume 55:Issue 11(2019)
• Page Start: 1651
• Page End: 1654
• Publication Date: 2019-01-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc09359h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel peptide-based four-color fluorescent polydopamine nanoprobe has been developed for multiplexed sensing and imaging of tumor-related proteases in living cells. This nanoprobe responds rapidly and selectively, enabling accurate differentiation between cancer cells and normal cells. Abstract : We develop a novel peptide-based four-color fluorescent polydopamine nanoprobe for multiplexed sensing and imaging of tumor-related proteases in living cells. This nanoprobe responds rapidly and selectively, enabling simultaneous and high-contrast imaging of multiple proteases in living cells. Furthermore, it could detect the changes of protease expression in living cells.