Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV). Issue 5 (1st March 2019)

• Record Type: Journal Article
• Authors: Magri, Andrea; Mokrane, Omar; Lauder, Kate; Patel, Arvind H.; Castagnolo, Daniele
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 29:Issue 5(2019)
• Page Start: 724
• Page End: 728
• Publication Date: 2019-03-01
• Subjects: HCV -- Amidinourea -- Polyamine -- HCV translation -- RNA IRES; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2019.01.008
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation.