Multi-successive-step pH sensitive procedure: Survey of dominant formation mechanism of therapeutic SPIONs. Issue 5 (1st April 2019)

• Record Type: Journal Article
• Authors: Ghazanfari, Mohammad Reza; Shams, S. Fatemeh; Jaafari, Mahmoud Reza; Kashefi, Mehrdad
• Is Part Of: Ceramics international. Volume 45:Issue 5(2019)
• Page Start: 6030
• Page End: 6036
• Publication Date: 2019-04-01
• Subjects: Magnetite nanoplatforms -- Chemical synthesis -- Reaction pathways -- X-ray diffractometry -- Intermediate phases; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2018.12.073
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: In the present study, multistep formation mechanism and synthesis reaction pathway of therapeutic magnetite nanoplatforms during a modified chemical coprecipitation method were identified. Critical reaction steps were considered through the study of pH variation trend as a function of structural, microstructural, and magnetic properties. Structural, microstructural, and magnetic characteristics were investigated using XRD, FT-IR, DLS, TEM, and VSM techniques. Results demonstrate the synthesis pathway of magnetite nanoparticles significantly depends on reaction pH and could be deduced in four successive transformation steps as follows: (I) initial materials to ferrous hydroxide, (II) ferrous hydroxide to lepidocrocite phase, (III) lepidocrocite to goethite phase, and (IV) goethite to magnetite (or/and maghemite) phase. Moreover, aqueous ferrofluids of synthesized Fe3 O4 nanoparticles demonstrate significant heat-generation ability and SAR values upon applying AC magnetic field which confirm their appropriate efficiency to utilize for therapeutic hyperthermia applications.