Β-Glucan successfully stimulated the immune system in different jawed vertebrate species. (February 2019)

• Record Type: Journal Article
• Authors: de Oliveira, Carlos A.F.; Vetvicka, Vaclav; Zanuzzo, Fábio S.
• Is Part Of: Comparative immunology, microbiology and infectious diseases. Volume 62(2019)
• Page Start: 1
• Page End: 6
• Publication Date: 2019-02
• Subjects: β-Glucan -- Immune response -- Mice -- Dog -- Piglets -- Chicken; Communicable diseases in animals -- Periodicals; Veterinary immunology -- Periodicals; Veterinary microbiology -- Periodicals; Immunology -- Periodicals; Microbiology -- Periodicals; Communicable diseases -- Periodicals; Communicable Diseases -- immunology -- Periodicals; Communicable Diseases -- veterinary -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Veterinary Medicine -- Periodicals; Immunologie -- Périodiques; Microbiologie -- Périodiques; Maladies infectieuses -- Périodiques; Communicable diseases; Immunology; Microbiology; Electronic journals; Periodicals; 636.08969
• DOI: 10.1016/j.cimid.2018.11.006
• Languages: English
• ISSNs: 0147-9571

Abstract

Highlights: Diets with two β-glucan molecules were examined in four vertebrate species. β-Glucans exhibited different magnitudes of effects on immune responses. β-Glucans promoted immune stimulation in immune responses in all species. Abstract: Several reports have shown the positive effects of β-glucans on the immune. Howeverthese studies have a broad experimental design including β-glucans compounds. Consequently, a study using the same β-glucan molecule, administration route and experimental design is needed to compare the effects of β-glucan across vertebrate species. For this end, during 28 days we fed four different vertebrate species: mice, dogs, piglets and chicks, with two β-glucan molecules (BG01 and BG02). We measured the serum interleukin 2 as an indicator of innate immune response, the neutrophils and monocytes phagocytosis index as a cellular response and antibody formation as an adaptive response. The results clearly showed that the different β-glucan molecules exhibited biologically differently behaviors, but both molecules stimulate the immune system in a similar pattern in these four species. This finding suggests that vertebrates shared similar mechanisms/patterns in recognizing the β-glucans and confirms the benefits of β-glucans across different vertebrate species.