From species diffusion to poroelasticity and the modeling of lamina cribrosa. (March 2019)

• Record Type: Journal Article
• Authors: Tatone, A.; Recrosi, F.; Repetto, R.; Guidoboni, G.
• Is Part Of: Journal of the mechanics and physics of solids. Volume 124(2019)
• Page Start: 849
• Page End: 870
• Publication Date: 2019-03
• Subjects: Diffusion -- Poroelasticity -- Soft tissues -- Hemodynamics -- Glaucoma -- Lamina cribrosa; Mechanics, Applied -- Periodicals; Solids -- Periodicals; Mechanics -- Periodicals; Mécanique appliquée -- Périodiques; Solides -- Périodiques; Mechanics, Applied; Solids; Periodicals; 531.05
• DOI: 10.1016/j.jmps.2018.11.017
• Languages: English
• ISSNs: 0022-5096

Abstract

Abstract: The Lamina Cribrosa is a part of the optic nerve head acting as a scaffold for collecting the retinal ganglion cell axons. It can be modeled as a poroelastic material where the saturated porosity stands for the capillary network running inside the collagen beams. Our aim is to study the interaction between tissue porosity, deformation and hemodynamics. To this end we first focus on the derivation of a poroelastic model in a rather general case, using as a prototype a model of species diffusion in an elastic material. Then we outline the clinical significance of the mechanical behavior of the Lamina Cribrosa and show, through numerical simulations, how an increased intraocular pressure results in a deformation affecting porosity and blood perfusion. We emphasize how the model behavior relies on the free energy expression.