Clinical Features of and Risk Factors for Hydrocephalus in Childhood Bacterial Meningitis. (January 2019)

• Record Type: Journal Article
• Authors: Huo, Liang; Fan, Yuying; Jiang, Chunying; Gao, Jian; Yin, Meng; Wang, Hua; Yang, Fenghua; Cao, Qingjun
• Is Part Of: Journal of child neurology. Volume 34:Number 1(2019:Jan.)
• Page Start: 11
• Page End: 16
• Publication Date: 2019-01
• Subjects: hydrocephalus -- meningitis -- bacterial -- children -- risk factors; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073818799155
• Languages: English
• ISSNs: 0883-0738

Abstract

Objective: To explore the clinical characteristics of and analyze the risk factors for hydrocephalus in children with bacterial meningitis. Methods: Retrospective study of a sample of children with bacterial meningitis seen on the pediatric service of Shengjing Hospital of China Medical University between January 1, 2010, and December 31, 2016. Results: Overall, 9.36% (25/267) of patients presented with hydrocephalus. Among patients with hydrocephalus, the age at onset of bacterial meningitis was usually <6 months, 15 patients had confirmed bacterial etiology, and 1 patient died. The most significant results of multivariate analysis for hydrocephalus were a rural living situation, altered level of consciousness, previous treatment with antibiotics, initial cerebrospinal fluid protein >2 g/L, C-reactive protein >100 mg/L, and dexamethasone use. Conclusions: A severe clinical manifestation and significant laboratory index at admission are the most important predictors of hydrocephalus in children with bacterial meningitis.