Two new tetracyclic triterpenoids from the endophytic fungus Hypoxylon sp. 6269. Issue 10 (3rd October 2018)

• Record Type: Journal Article
• Authors: Liang, Han-Qiao; Zhang, Da-Wei; Guo, Shun-Xing; Yu, Jie
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 10(2018)
• Page Start: 951
• Page End: 956
• Publication Date: 2018-10-03
• Subjects: Endophytic fungus -- tetracyclic triterpenoids -- Hypoxylon sp -- HIV-1 integrase; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1485662
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new tetracyclic triterpenoids, integracide E (1 ) and isointegracide E (2 ), as well as three known secondary metabolites (i.e. integracide A (3 ), 2-deoxyintegracide A (4 ) and 2-deoxyintegracide B (5 )), were isolated from mycelium of the endophytic fungus Hypoxylon sp. 6269. Structures were determined by a combination of 1D and 2D NMR techniques and mass spectrometry. All of the compounds were tested for their anti-HIV-1 integrase activities. Abstract :