Evaluation and prediction of powder flowability in pharmaceutical tableting. (2nd January 2019)

• Record Type: Journal Article
• Authors: Hildebrandt, Claudia; Gopireddy, Srikanth R.; Fritsch, Alexander K.; Profitlich, Thomas; Scherließ, Regina; Urbanetz, Nora A.
• Is Part Of: Pharmaceutical development and technology. Volume 24:Number 1(2019)
• Page Start: 35
• Page End: 47
• Publication Date: 2019-01-02
• Subjects: Model die filling -- die fill index -- tableting -- flowability prediction -- direct compression; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.1080/10837450.2017.1412462
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: The focus of this study is to establish a characterization method determining the powder flowability in context of tableting. At first, flowability of different materials is measured using the ring shear tester, and its prediction from particle size is established. Next, the model die-filling system is presented which is a modified version of previous studies. Using this system, flowability of different materials is measured at varying die speeds. A new curve fit to assess die fill ratio vs die speed is suggested improving predictability, and a novel flowability metric, " Die Fill Index " ( DFI ), is derived. The DFI is appropriate to describe flowability for most of the tested materials, and sensitivity of a material with respect to tableting speed. A correlation is generated predicting DFI from particle size. Additionally, it is shown that model die filling is the preferable method to assess flowability for tableting compared to ring shear tester.