Delivery of alpha-tocopherol through soluble dietary fibre-based nanofibres for improving the life span of Caenorhabditis elegans. (17th February 2019)

• Record Type: Journal Article
• Authors: Li, Juan; Chotiko, Arranee; Chouljenko, Alexander; Gao, Chenfei; Zheng, Jolene; Sathivel, Subramaniam
• Is Part Of: International journal of food sciences and nutrition. Volume 70:Number 2(2019)
• Page Start: 172
• Page End: 181
• Publication Date: 2019-02-17
• Subjects: C. elegans -- soluble dietary fibre -- nanofibre -- alpha-tocopherol -- life span -- pharyngeal pumping rate; Food -- Analysis -- Periodicals; Nutrition -- Periodicals; 641.3
• DOI: 10.1080/09637486.2018.1489785
• Languages: English
• ISSNs: 0963-7486

Abstract

Abstract: The effect of alpha-tocopherol (α-TOC) delivered by soluble dietary fibre-based nanofibres (α-TOC-SDNF) on the life span of nematode Caenorhabditis elegans N2 (wild type) and TK22 ( mev-1 mutants) with and without heat shock was investigated. Without heat shock, the wild-type and mev-1 mutants maintained in the 100 µg/mL of α-TOC-SDNF had longer life spans than their respective blank control groups. With heat shock, the wild-type N2 in the 200 µg/mL of α-TOC-SDNF had a survival rate of 5% at day 49, while no nematodes survived in the blank control group. An increased pharyngeal pumping rate was observed in the α-TOC-SDNF treated mev-1 mutants worms compared to the blank control group. Encapsulating α-TOC in SDNF yielded protective effects and the life span and pumping rate of C. elegans was increased with α-TOC delivered by SDNF. Abstract :