I2-catalyzed intramolecular oxidative amination of C(sp3)–H bond: efficient access to 3-acylimidazo[1, 2-a]pyridines under neat condition. Issue 5 (18th January 2019)

• Record Type: Journal Article
• Authors: Huang, Lilan; Yin, Wenqing; Wang, Jian; Gan, Chunfang; Huang, Yanmin; Huang, Chusheng; He, Yimiao
• Is Part Of: RSC advances. Volume 9:Issue 5(2019)
• Page Start: 2381
• Page End: 2385
• Publication Date: 2019-01-18
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra10118c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An efficient and green protocol for the synthesis of 3-acylimidazo[1, 2- a ]pyridines utilizing I2 as a catalyst and H2 O2 as an oxidant under neat condition or in water was developed. Abstract : An efficient and "green" protocol for the synthesis of 3-acylimidazo[1, 2- a ]pyridines through intramolecular oxidative α-amination of carbonyl compounds has been developed. The reaction proceeds smoothly utilizing I2 as a catalyst and H2 O2 as an oxidant under neat condition with broad substrate scope. Several complex nitrogen-containing fused rings are conveniently constructed, which are not easy to access by traditional methods.