Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase. Issue 1 (8th January 2019)
- Record Type:
- Journal Article
- Title:
- Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase. Issue 1 (8th January 2019)
- Main Title:
- Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase
- Authors:
- Yang, Ling-Ling
Xu, Wei
Yan, Jie
Su, Hui-Lin
Yuan, Chen
Li, Chao
Zhang, Xing
Yu, Zhu-Jun
Yan, Yu-Hang
Yu, Yamei
Chen, Qiang
Wang, Zhouyu
Li, Lin
Qian, Shan
Li, Guo-Bo - Abstract:
- Abstract : A high-quality X-ray crystal structure reveals the mechanism of compound1a inhibiting SIRT2 deacetylase and decanoylase. Abstract : A high-quality X-ray crystal structure reveals the mechanism of compound1a inhibiting SIRT2 deacetylase and decanoylase. Structure–activity relationship (SAR) analysis of the synthesized derivatives of1a reveals the high requirements needed for selective inhibitors to bind with the induced hydrophobic pocket and potently inhibit sirtuin 2 deacetylase.
- Is Part Of:
- MedChemComm. Volume 10:Issue 1(2019)
- Journal:
- MedChemComm
- Issue:
- Volume 10:Issue 1(2019)
- Issue Display:
- Volume 10, Issue 1 (2019)
- Year:
- 2019
- Volume:
- 10
- Issue:
- 1
- Issue Sort Value:
- 2019-0010-0001-0000
- Page Start:
- 164
- Page End:
- 168
- Publication Date:
- 2019-01-08
- Subjects:
- Pharmaceutical chemistry -- Periodicals
615.19 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/md ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c8md00462e ↗
- Languages:
- English
- ISSNs:
- 2040-2503
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5424.685000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 9443.xml