Biphenyl Derivatives from the Aerial Parts of Oenanthe javanica and Their COX‐2 Inhibitory Activities. Issue 1 (28th December 2018)

• Record Type: Journal Article
• Authors: Ma, Qin‐Ge; Wei, Rong‐Rui; Sang, Zhi‐Pei
• Is Part Of: Chemistry & biodiversity. Volume 16:Issue 1(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-28
• Subjects: Oenanthe javanica -- biphenyl derivative -- COX-2 inhibitory activity -- phytochemistry -- biological activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201800480
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Four new biphenyl derivatives (1 –4 ), along with six known biphenyl derivatives (5 –10 ) were isolated and elucidated by their detailed analyses of spectroscopic data and references from the aerial parts of Oenanthe javanica for the first time. Compounds (1 –10 ) were assayed for their activities about the inhibition of COX‐2 enzyme in vitro for the first time. Compounds1, 2, 4, and6 showed inhibitory activities against COX‐2 with IC50 values ranging from 22.18±0.29 to 108.54±0.42 μm . Abstract :