Translational regulation in response to stress in Saccharomyces cerevisiae. Issue 1 (3rd September 2018)

• Record Type: Journal Article
• Authors: Crawford, Robert A.; Pavitt, Graham D.
• Other Names: Tuite Mick guestEditor.
• Is Part Of: Yeast. Volume 36:Issue 1(2019:Jan.)
• Page Start: 5
• Page End: 21
• Publication Date: 2018-09-03
• Subjects: translational control -- RNA‐binding proteins -- eIF2 phosphorylation -- ribosome filter -- specialized ribosomes; Yeast -- Periodicals; Yeasts -- Periodicals; Yeasts -- genetics -- Periodicals; Electronic journals; 547
• DOI: 10.1002/yea.3349
• Languages: English
• ISSNs: 0749-503X

Abstract

Abstract: The budding yeast Saccharomyces cerevisiae must dynamically alter the composition of its proteome in order to respond to diverse stresses. The reprogramming of gene expression during stress typically involves initial global repression of protein synthesis, accompanied by the activation of stress‐responsive mRNAs through both translational and transcriptional responses. The ability of specific mRNAs to counter the global translational repression is therefore crucial to the overall response to stress. Here we summarize the major repressive mechanisms and discuss mechanisms of translational activation in response to different stresses in S. cerevisiae . Taken together, a wide range of studies indicate that multiple elements act in concert to bring about appropriate translational responses. These include regulatory elements within mRNAs, altered mRNA interactions with RNA‐binding proteins and the specialization of ribosomes that each contribute towards regulating protein expression to suit the changing environmental conditions.