Platelet‐Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury. (13th November 2018)

• Record Type: Journal Article
• Authors: Su, Teng; Huang, Ke; Ma, Hong; Liang, Hongxia; Dinh, Phuong‐Uyen; Chen, Justin; Shen, Deliang; Allen, Tyler A.; Qiao, Li; Li, Zhenhua; Hu, Shiqi; Cores, Jhon; Frame, Brianna N.; Young, Ashlyn T.; Yin, Qi; Liu, Jiandong; Qian, Li; Caranasos, Thomas G.; Brudno, Yevgeny; Ligler, Frances S.; Cheng, Ke
• Is Part Of: Advanced functional materials. Volume 29:Number 4(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-13
• Subjects: biomimetics -- drug delivery -- ischemic injury -- platelets -- stromal cell secretome; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201803567
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy is vital for patient survival post‐heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. Exploring ways to attenuate I/R injury is of clinical interest for improving post‐ischemic recovery. A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2 )‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced. By taking advantage of the natural infarct‐homing ability of platelet membrane and the overexpression of PGE2 receptors (EPs) in the pathological cardiac microenvironment after I/R injury, the PINCs can achieve targeted delivery of therapeutic payload to the injured heart. Furthermore, a synergistic treatment efficacy can be achieved by PINC, which combines the paracrine mechanism of cell therapy with the PGE2 /EP receptor signaling that is involved in the repair and regeneration of multiple tissues. In a mouse model of myocardial I/R injury, intravenous injection of PINCs results in augmented cardiac function and mitigated heart remodeling, which is accompanied by the increase in cycling cardiomyocytes, activation of endogenous stem/progenitor cells, and promotion of angiogenesis. This approach represents a promising therapeutic delivery platform for treating I/R injury. Abstract : A platelet‐inspired nanocell (PINC) dually targeting heart injury is introduced that incorporates both prostaglandin E2 (PGE2 )‐modified platelet membrane and cardiac stromal cell‐secreted factors, resulting in synergistic treatment efficacy which combines the paracrine mechanism of cell therapy with the PGE2 /EP receptor signaling that is involved in the repair and regeneration of ischemic heart tissue.