Dose-response effects of omega-3 on platelet aggregation: an observational study. Issue 12 (December 2018)

• Record Type: Journal Article
• Authors: Kander, Thomas; Lindblom, Erik; Schött, Ulf
• Is Part Of: Journal of international medical research. Volume 46:Issue 12(2018)
• Page Start: 5074
• Page End: 5082
• Publication Date: 2018-12
• Subjects: Thrombocyte -- platelet aggregation assay -- alternative medicine -- fish oil -- omega-3 fatty acids -- arachidonic acid; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060518789817
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers. Methods: Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids. Results: There were no differences in platelet aggregation measured by the MEA assay in healthy volunteers after intake of either the normal or high dose of omega-3 fatty acids. In the in vitro experiment, a platelet-inhibiting effect of omega-3 fatty acids was shown by an arachidonic acid agonist in MEA . Conclusions: Supplemental omega-3 fatty acids do not evoke their positive health effects through inhibition of platelet aggregation measurable with MEA.