Expression of β-catenin in human trophoblast and its role in placenta accreta and placenta previa. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Han, Qing; Zheng, Lianghui; Liu, Zhaodong; Luo, Jinying; Chen, Rongxin; Yan, Jianying
• Is Part Of: Journal of international medical research. Volume 47:Issue 1(2019)
• Page Start: 206
• Page End: 214
• Publication Date: 2019-01
• Subjects: β-catenin -- placenta accreta -- placenta previa -- pathogenesis -- trophoblasts -- placenta -- birth weight -- trophoblastic invasion; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060518799265
• Languages: English
• ISSNs: 0300-0605

Abstract

Objectives: To investigate the expression of β-catenin in chorionic villi, and to explore its roles in placenta accreta and placenta previa. Methods: We compared β-catenin expression in the control group, placenta accreta group (lesion area and normal zones), and placenta previa group (placental central and placental edge zones) by immunohistochemistry, Western blotting, and RT-PCR techniques. Results: Compared with the normal group, the placenta accreta group had a longer length of stay, greater bleeding volume, and lower newborn birth weight. Further, the expression of β-catenin was lower in both placenta previa and placenta accreta groups than in the control group, as measured by immunohistochemistry. Compared with the control group, expression of β-catenin was significantly lower in the placenta previa and placenta accreta groups by Western blotting and RT-PCR. Importantly, the level of placental β-catenin was significantly different when compared between the lesion and normal zones of placenta. Conclusion: The expression of β-catenin in placenta accreta might play an important role in the regulation of placental cell invasion; low expression of β-catenin in placenta accreta might be responsible for excessive trophoblastic invasion.