RNA processing in skeletal muscle biology and disease. Issue 1 (1st January 2019)

• Record Type: Journal Article
• Authors: Hinkle, Emma R; Wiedner, Hannah J; Black, Adam J; Giudice, Jimena
• Is Part Of: Transcription. Volume 10:Issue 1(2019)
• Page Start: 1
• Page End: 20
• Publication Date: 2019-01-01
• Subjects: RNA processing -- skeletal muscle -- alternative splicing -- transcription -- epigenetics; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2018.1558677
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: RNA processing encompasses the capping, cleavage, polyadenylation and alternative splicing of pre-mRNA. Proper muscle development relies on precise RNA processing, driven by the coordination between RNA-binding proteins. Recently, skeletal muscle biology has been intensely investigated in terms of RNA processing. High throughput studies paired with deletion of RNA-binding proteins have provided a high-level understanding of the molecular mechanisms controlling the regulation of RNA-processing in skeletal muscle. Furthermore, misregulation of RNA processing is implicated in muscle diseases. In this review, we comprehensively summarize recent studies in skeletal muscle that demonstrated: (i) the importance of RNA processing, (ii) the RNA-binding proteins that are involved, and (iii) diseases associated with defects in RNA processing.