Caffeine intake is not associated with serum testosterone levels in adult men: cross-sectional findings from the NHANES 1999–2004 and 2011–2012. (2nd January 2019)

• Record Type: Journal Article
• Authors: Lopez, David S.; Advani, Shailesh; Qiu, Xueting; Tsilidis, Konstantinos K.; Khera, Mohit; Kim, Jeri; Canfield, Steven
• Is Part Of: Aging male. Volume 22:Number 1(2019)
• Page Start: 45
• Page End: 54
• Publication Date: 2019-01-02
• Subjects: Caffeine intake -- testosterone -- race/ethnicity -- obesity; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.1080/13685538.2018.1465912
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Objective: The association of caffeine intake with testosterone remains unclear. We evaluated the association of caffeine intake with serum testosterone among American men and determined whether this association varied by race/ethnicity and measurements of adiposity. Methods: Data were analyzed for 2581 men (≥20 years old) who participated in the cycles of the NHANES 1999–2004 and 2011–2012, a cross-sectional study. Testosterone (ng/mL) was measured by immunoassay among men who participated in the morning examination session. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable weighted linear regression models were conducted. Results: We identified no linear relationship between caffeine intake and testosterone levels in the total population, but there was a non-linear association ( p nonlinearity < .01). Similarly, stratified analysis showed nonlinear associations among Mexican-American and Non-Hispanic White men ( p nonlinearity ≤ .03 both) and only among men with waist circumference <102 cm and body mass index <25 kg/m 2 ( p nonlinearity < .01, both). Conclusion: No linear association was identified between levels of caffeine intake and testosterone in US men, but we observed a non-linear association, including among racial/ethnic groups and measurements of adiposity in this cross-sectional study. These associations are warranted to be investigated in larger prospective studies.