Low body mass index and efavirenz use are independently associated with self-reported fatigue in HIV-infected patients. Issue 4 (3rd April 2019)

• Record Type: Journal Article
• Authors: Wang, Keran; Lin, Haijiang; Li, Lingling; Wu, Qionghai; Shen, Weiwei; Liu, Xing; Gao, Meiyang; Zhou, Sujuan; Ding, Yingying; He, Na
• Is Part Of: AIDS care. Volume 31:Issue 4(2019)
• Page Start: 513
• Page End: 518
• Publication Date: 2019-04-03
• Subjects: Human immunodeficiency virus -- self-reported fatigue -- efavirenz -- body mass index; AIDS (Disease) -- Social aspects -- Periodicals; AIDS (Disease) -- Psychological aspects -- Periodicals; AIDS (Disease) -- Patients -- Care -- Periodicals; Acquired Immunodeficiency Syndrome; 362.1969792
• DOI: 10.1080/09540121.2018.1524110
• Languages: English
• ISSNs: 0954-0121

Abstract

ABSTRACT: This retrospective cohort study was conducted from January 2009 to July 2016 to explore the occurrence and risk factors of self-reported fatigue within the first 6 months after receiving antiretroviral treatment (ART) among patients living with HIV in Taizhou City of Zhejiang province, Eastern China. In total, 1163 HIV-infected patients with a median follow-up duration of 27.8 months were included in the analysis. Among them, 261 (22.4%) reported fatigue within the first 6 months after ART. In the multivariable logistic regression analysis, self-reported fatigue within the first 6 months after ART was negatively associated with junior middle-school education or above, baseline CD4 cell count of 200–349 and >350 cells/μL (vs < 200 cells/μL), overweight at baseline (vs normal weight) but positively associated with ≥50 years old at initiation of ART (vs <30 years old), underweight at baseline, use of efavirenz (EFV) in the first-line regimen. Our data suggest that earlier initiation of ART and higher body mass index are preferred to restore the energy of HIV-infected patients with the EFV use in the era of ART in China.