Pharmacokinetic and anti-colon cancer properties of curcumin-containing chitosan-pectinate composite nanoparticles. Issue 18 (12th December 2018)

• Record Type: Journal Article
• Authors: Alkhader, Enas; Roberts, Clive J.; Rosli, Rozita; Yuen, Kah Hay; Seow, Eng Kwong; Lee, You Zhuan; Billa, Nashiru
• Is Part Of: Journal of biomaterials science. Volume 29:Issue 18(2018)
• Page Start: 2281
• Page End: 2298
• Publication Date: 2018-12-12
• Subjects: Curcumin -- Colorectal cancer -- Cellular uptake -- Nanoparticles -- Pharmacokinetics; Polymers -- Biocompatibility -- Periodicals; Biomedical materials -- Periodicals; 572.33
• DOI: 10.1080/09205063.2018.1541500
• Languages: English
• ISSNs: 0920-5063

Abstract

Abstract: Curcumin, the active ingredient of the rhizome curcuma longa has been extensively studied as an anticancer agent for various types of tumours. However, its efficacy as an anticancer agent is restricted due to poor absorption from the gastrointestinal tract, rapid metabolism and degradation in acidic medium. In the present study, we encapsulated curcumin in chitosan-pectinate nanoparticulate system (CUR-CS-PEC-NPs) for deployment of curcumin to the colon, whereby curcumin is protected against degradative effects in the upper digestive tract, and hence, maintaining its anticancer properties until colon arrival. The CUR-CS-PEC-NPs was taken up by HT-29 colorectal cancer cells which ultimately resulted in a significant reduction in cancer cell propagation. The anti-proliferative effect of the encapsulated curcumin was similar to that of free curcumin at equivalent doses which confirms that the encapsulation process did not impede the anticancer activity of curcumin. The oral bioavailability (Cmax, and AUC) of curcumin in CUR-CS-PEC-NPs was enhanced significantly by 4-folds after 6 hours of treatment compared to free curcumin. Furthermore, the clearance of curcumin from the CUR-CS-PEC-NPs was lower compared to free curcumin. These findings point to the potential application of the CUR-CS-PEC-NPs in the oral delivery of curcumin in the treatment of colon cancer.