The use of terpenes and derivatives as a new perspective for cardiovascular disease treatment: a patent review (2008–2018). (2nd January 2019)

• Record Type: Journal Article
• Authors: Silva, Eric Aian P.; Carvalho, Jéssica S.; Guimarães, Adriana G.; Barreto, Rosana de S.S.; Santos, Márcio R.V.; Barreto, André S.; Quintans-Júnior, Lucindo J.
• Is Part Of: Expert opinion on therapeutic patents. Volume 29:Number 1(2019)
• Page Start: 43
• Page End: 53
• Publication Date: 2019-01-02
• Subjects: Cardiovascular agents -- pharmaceutical preparation -- terpenes -- terpenoid; Drugs -- Patents -- Periodicals; 615.10272
• DOI: 10.1080/13543776.2019.1558211
• Languages: English
• ISSNs: 1354-3776

Abstract

ABSTRACT: Introduction : Terpenes are a class of secondary metabolites that can be found in a variety of animal and plants species. They are considered the most structurally diversified and abundant of all natural compounds. Several studies have shown the application of terpenes, such as carvacrol, linalool, and limonene in many pharmaceutical and medicinal fields, including cardiovascular disorders, the leading cause of death worldwide.Areas covered : In this review, the authors outlined patents from the last 10 years relating to the therapeutic application of terpenes for the treatment and/or prevention of cardiovascular diseases found in different databases, emphasizing the possibility of these compounds becoming new drugs that may help to decrease the burden of these disorders.Expert opinion : There has been a growing awareness over recent years of the therapeutic use of terpenes and their derivatives as new pharmaceutical products. Patents involving the use of terpenes have been especially important in the technological development of new strategies for the treatment of cardiovascular diseases by bringing new scientific knowledge into the pharmaceutical industry. Therefore, the development of biotechnologies using natural products should be encouraged in order to increase the variety of drugs available for the treatment of cardiovascular diseases.