Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines. Issue 3 (11th January 2019)

• Record Type: Journal Article
• Authors: Rzhevskiy, Sergey A.; Ageshina, Alexandra A.; Chesnokov, Gleb A.; Gribanov, Pavel S.; Topchiy, Maxim A.; Nechaev, Mikhail S.; Asachenko, Andrey F.
• Is Part Of: RSC advances. Volume 9:Issue 3(2019)
• Page Start: 1536
• Page End: 1540
• Publication Date: 2019-01-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra10040c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A new environmentally friendly approach to transition metal- and solvent-free amide synthesis from aryl esters and aryl amines is described. Abstract : A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.