A novel fluorescent turn-on probe for imaging biothiols based on SNAr substitution-skeletal rearrangement strategy. Issue 3 (8th January 2019)

• Record Type: Journal Article
• Authors: Ren, Aishan; Zhu, Dongjian; Zhong, Xing; Xiong, Yuhao; Duan, Zhenhua
• Is Part Of: Analytical methods. Volume 11:Issue 3(2019)
• Page Start: 262
• Page End: 267
• Publication Date: 2019-01-08
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c8ay02413h
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : 2 is a novel fluorescent turn-on probe for imaging biothiols based on SN Ar substitution-skeletal rearrangement strategy with dramatic fluorescence enhancement and high sensitivity. Abstract : A novel fluorescent turn-on probe2 not only exhibited dramatic fluorescence enhancement by quinoline-to-quinolinone transformation, but also showed high sensitivity in the order Cys > GSH > Hcy. Importantly, 2 was successfully applied for imaging of biothiols in living cells.