Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery. Issue 8 (11th January 2019) - Zhang, Yu-Hui
Abstract : A polysaccharide nanoconjugate was fabricated from N -(2-aminoethyl)-gluconamide-grafted hyaluronic acid and bortezomib, displaying pH-responsive targeted drug release and higher anticancer effect. Abstract : A pH-responsive and targeted polysaccharide conjugate was fabricated from the boronate linkage of N -(2-aminoethyl)-gluconamide-grafted hyaluronic acid with anticancer drug bortezomib, which could exhibit targeted drug release behaviors at acidic pH and possess lower cytotoxicity and a higher inhibition effect toward cancer cells.