Isolation of maltol derivatives from Stellera chamaejasme and the anti-atopic properties of maltol on skin lesions in DNCB-stimulated mice. Issue 4 (15th January 2019)

• Record Type: Journal Article
• Authors: Jo, Beom-Geun; Park, No-June; Kim, Su-Nam; Jegal, Jonghwan; Choi, Sangho; Lee, Sang Woo; Yi, Li Wan; Lee, Seoung Rak; Kim, Ki Hyun; Yang, Min Hye
• Is Part Of: RSC advances. Volume 9:Issue 4(2019)
• Page Start: 2125
• Page End: 2132
• Publication Date: 2019-01-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra09743g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The aim of this study was to isolate maltol derivatives from S. chamaejasme and to investigate the anti-atopic dermatitis (anti-AD) effect of maltol in a 2, 4-dinitrochlorobenzene (DNCB)-sensitized mouse model of AD. Abstract : The aim of this study was to isolate maltol derivatives from S. chamaejasme and to investigate the anti-atopic dermatitis (anti-AD) effect of maltol in a 2, 4-dinitrochlorobenzene (DNCB)-sensitized mouse model of AD. A novel compound, maltol 3- O -(4′- O-cis-p -coumaroyl)- β -d -glucoside (named isosoyamaloside I), and two known maltol derivatives (maltol and soyamaloside I) were isolated from S. chamaejasme using chromatographic methods. Dermal application of maltol to DNCB-sensitized AD mice reduced erythema, pruritus, and lichenification scores. Histopathological examinations revealed significant decline in mast cell infiltration in maltol-treated AD mice. In addition, maltol accelerated skin barrier recovery by reducing TEWL and skin pH and increasing skin hydration. Maltol was also found to suppress atopy-induced IL-4 and IgE elevations in serum, which are known to be essential for the development of atopy. The results of this study show that maltol is a potential therapeutic candidate for the treatment of AD-related skin diseases.