Dose-response relationships between polycyclic aromatic hydrocarbons exposure and platelet indices. (February 2019)

• Record Type: Journal Article
• Authors: Yuan, Chunjie; Hou, Jian; Zhou, Yun; Hu, Chen; Sun, Huizhen; Chen, Weihong; Yuan, Jing
• Is Part Of: Environmental pollution. Volume 245(2019)
• Page Start: 183
• Page End: 198
• Publication Date: 2019-02
• Subjects: Polycyclic aromatic hydrocarbons -- Platelet -- Human exposure; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2018.10.127
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: The relations of polycyclic aromatic hydrocarbons (PAHs) exposure with platelet indices remain unclear. Based on the baseline data from the Wuhan-Zhuhai Cohort Study, we used generalized linear model, multivariate logistic regression analysis and restricted cubic splines (RCS) to assess linear and nonlinear relationship of PAHs exposure with platelet indices. The results showed that among Wuhan individuals, there were the non-linear relations between total hydroxynaphthalene (ΣOHNa) and mean platelet volume (MPV) or ratio of mean platelet volume to platelet count (MPVP), total hydrophenanthrene (ΣOHPh) and MPV or platelet distribution width (PDW), the sum concentration of urinary monohydroxylated metabolites of PAHs (ΣOH-PAHs) and ratio of platelet count to lymphocyte count (PLR) or MPVP, 1-hydropyrene (1-OHP) and PLR or PDW. But among Zhuhai individuals, neither linear nor non-linear relations were found between each of OH-PAHs or ΣOH-PAHs and platelet indices. The findings indicate that serum MPV and MPVP may be independent biomarkers of effects of exposing to environmental PAHs on human bodies. Graphical abstract: Highlights: Wuhan individuals had higher levels of 8 OH-PAHs and ΣOH-PAHs than Zhuhai ones. Wuhan individuals with high OH-PAHs had longitudinal changes in platelet indices. Wuhan individuals with high OH-PAHs were at high risk of increased MPV and MPVP. Relations of certain OH-PAHs with platelet indices were non-linear in Wuhan ones. Abstract : Serum MPV and MPVP may be independent biomarkers for affecting adverse effects of environmental PAHs exposure on human bodies.