Nucleus–Invadopodia Duo During Cancer Invasion. Issue 2 (February 2019)

• Record Type: Journal Article
• Authors: Ferrari, Robin; Infante, Elvira; Chavrier, Philippe
• Is Part Of: Trends in cell biology. Volume 29:Issue 2(2019)
• Page Start: 93
• Page End: 96
• Publication Date: 2019-02
• Subjects: invadopodia -- MT1-MMP -- microtubule -- LINC complex -- tumor invasion -- centrosome; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2018.11.006
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : Matrix proteolysis mediated by MT1-MMP facilitates the invasive migration of tumor cells in dense tissues, which otherwise get trapped in the matrix because of limited nuclear deformability. A digest-on-demand response has been identified, which requires nucleus–microtubule linkage through the LINC complex and triggers MT1-MMP surface-exposure to facilitate nucleus movement.