Comparison of long-term clinical outcomes between revascularization versus medical treatment in patients with silent myocardial ischemia. (15th February 2019)

• Record Type: Journal Article
• Authors: Choi, Ki Hong; Lee, Joo Myung; Park, Il; Kim, Jihoon; Rhee, Tae-Min; Hwang, Doyeon; Park, Jonghanne; Park, Taek Kyu; Yang, Jeong Hoon; Song, Young Bin; Hahn, Joo-Yong; Jeong, Dong Seop; Cho, Yang Hyun; Kim, Wook Sung; Sung, Kiick; Jang, Mi Ja; Sung, Ji Dong; Choi, Jin-Ho; Choi, Seung-Hyuk; Koo, Bon-Kwon; Lee, Young Tak; Kim, Eun Kyoung; Chang, Sung A.; Park, Sung-Ji; Choi, Jin-Oh; Lee, Sang-Chol; Park, Seung Woo; Cho, Young Seok; Choi, Joon Young; Gwon, Hyeon-Cheol; Oh, Jae K.;
• Is Part Of: International journal of cardiology. Volume 277(2019)
• Page Start: 47
• Page End: 53
• Publication Date: 2019-02-15
• Subjects: CABG coronary artery bypass graft surgery -- CAD coronary artery disease -- CI confidence intervals -- DES drug-eluting stent -- HR hazard ratio -- IPW inverse-probability-weighted -- LVEF left ventricular ejection fraction -- MI myocardial infarction -- MT medical treatment -- PCI percutaneous coronary intervention -- SPECT single-photon emission computed tomography; Percutaneous coronary intervention -- Coronary artery bypass graft surgery -- Silent myocardial ischemia -- Coronary artery disease -- Outcomes; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2018.08.006
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: There have been limited and conflicting results regarding the prognostic impact of revascularization treatment on the long-term clinical outcomes of silent ischemia. The current study aimed to determine whether revascularization treatment compared with medical treatment (MT) alone reduces long-term risk of cardiac death of asymptomatic patients with objective evidence of inducible myocardial ischemia. Methods: A total of 1473 consecutive asymptomatic patients with evidence of inducible myocardial ischemia were selected from a prospective institutional registry. All patients showed at least 1 epicardial coronary stenosis with ≥50% diameter stenosis in coronary angiography. Patients were classified according to their treatment strategies. The primary outcome was cardiac death up to 10 years. Results: Among the total population, 709 patients (48.1%) received revascularization treatment including percutaneous coronary intervention (PCI, n = 558) or coronary artery bypass graft surgery (CABG, n = 151), with the remaining patients (764 patients, 51.9%) receiving MT alone. During the follow-up period, the revascularization treatment group showed a significantly lower risk of cardiac death compared with the MT alone group (25.4% vs. 33.7%, HR 0.624, 95%CI 0.498–0.781, p < 0.001). Among revascularized patients, patients with negative non-invasive stress test results after revascularization showed significantly lower risk of cardiac death compared to those with residual myocardial ischemia (8.9% vs. 18.7%, HR 0.406, 95% CI 0.175–0.942, p = 0.036). Conclusions: In patients with silent myocardial ischemia, revascularization treatment was associated with significantly lower long-term risk of cardiac death compared with the MT alone group. The current results support contemporary practice of ischemia-directed revascularization, even in patients with silent myocardial ischemia. Highlights: In patients with silent ischemia, the role of revascularization is uncertain and previous studies show conflicting results. This study showed a significantly lower risk of mortality in the revascularization group than in the medical treatment group. Patients with resolution of ischemia showed significantly lower risk of cardiac death than those with residual ischemia after PCI.