The circadian clock in adult neural stem cell maintenance. (February 2019)

• Record Type: Journal Article
• Authors: Draijer, Swip; Chaves, Inês; Hoekman, Marco F.M.
• Is Part Of: Progress in neurobiology. Volume 173(2019)
• Page Start: 41
• Page End: 53
• Publication Date: 2019-02
• Subjects: BMAL1 brain and muscle ARNT-like protein 1 -- CLOCK Circadian Locomotor Output Cycles Kaput -- PER period -- CRY cryptochrome -- ROR RAR-related orphan receptor -- DBP D-box binding protein -- qNSC quiescent neural stem cell -- aNSC activated neural stem cell -- SIRT1 NAD-dependent protein deacetylase sirtuin-1 -- HDAC histone deacetylase -- HAT histone acetyltransferase -- Nampt nicotinamide phosphoribosyltransferase -- SCN suprachiasmatic nucleus -- SGZ subgranular zone -- SVZ subventricular zone; Circadian rhythms -- Neural stem cell -- Quiescence -- SIRT1 -- Metabolism -- Aging; Neurobiology -- Periodicals; Neurology -- Periodicals; Neurology -- Periodicals; Neurobiologie -- Périodiques; 612.8
• DOI: 10.1016/j.pneurobio.2018.05.007
• Languages: English
• ISSNs: 0301-0082

Abstract

Highlights: The circadian clock regulates maintenance of neural stem cells. Metabolism modulates both neural stem cell fates and circadian clock machinery. Disruption of the circadian clock causes loss of quiescence resulting indepletion of the neural stem cell population. We propose that the NAD + -dependent deacetylase SIRT1 mediates neural stem cell fates by modulating the circadian clock. Abstract: Neural stem cells persist in the adult central nervous system as a continuing source of astrocytes, oligodendrocytes and neurons. Various signalling pathways and transcription factors actively maintain this population by regulating cell cycle entry and exit. Similarly, the circadian clock is interconnected with the cell cycle and actively maintains stem cell populations in various tissues. Here, we discuss emerging evidence for an important role of the circadian clock in neural stem cell maintenance. We propose that the NAD + -dependent deacetylase SIRT1 exerts control over the circadian clock in adult neural stem cell function to limit exhaustion of their population. Conversely, disruption of the circadian clock may compromise neural stem cell quiescence resulting in a premature decline of the neural stem cell population. As such, energy metabolism and the circadian clock converge in adult neural stem cell maintenance.