Encounter and React: Computer-Guided Design of Covalent Inhibitors. Issue 1 (17th January 2019)

• Record Type: Journal Article
• Authors: Ung, Peter Man-Un; DeVita, Robert J.; Schlessinger, Avner
• Is Part Of: Cell chemical biology. Volume 26:Issue 1(2019)
• Page Start: 6
• Page End: 8
• Publication Date: 2019-01-17
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2018.12.009
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : Covalent inhibitors can obtain optimal selectivity and extended residence time. In this issue of Cell Chemical Biology, Shraga et al. (2019) take a comprehensive computational and experimental approach to modulate the JNK-Jun pathway through design of MKK7 covalent inhibitors. This study highlights a promising and emerging strategy for therapeutic discovery. Abstract : Covalent inhibitors can obtain optimal selectivity and extended residence time. In this issue of Cell Chemical Biology, Shraga et al. (2019) take a comprehensive computational and experimental approach to modulate the JNK-Jun pathway through design of MKK7 covalent inhibitors. This study highlights a promising and emerging strategy for therapeutic discovery.