Phospholipase C-β1 interacts with cyclin E in adipose- derived stem cells osteogenic differentiation. (January 2019)

• Record Type: Journal Article
• Authors: Ramazzotti, Giulia; Fiume, Roberta; Chiarini, Francesca; Campana, Gabriele; Ratti, Stefano; Billi, Anna Maria; Manzoli, Lucia; Follo, Matilde Y.; Suh, Pann-Gill; McCubrey, James; Cocco, Lucio; Faenza, Irene
• Is Part Of: Advances in biological regulation. Volume 71(2019)
• Page Start: 1
• Page End: 9
• Publication Date: 2019-01
• Subjects: PLC-β1 -- Cyclin E -- Adipose derived stem cells -- Stem cell differentiation -- Osteogenesis; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2018.11.001
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: Adipose-derived stem cells (ADSCs) are multipotent mesenchymal stem cells that have the ability to differentiate into several cell types, including chondrocytes, osteoblasts, adipocytes, and neural cells. Given their easy accessibility and abundance, they became an attractive source of mesenchymal stem cells, as well as candidates for developing new treatments for reconstructive medicine and tissue engineering. Our study identifies a new signaling pathway that promotes ADSCs osteogenic differentiation and links the lipid signaling enzyme phospholipase C (PLC)-β1 to the expression of the cell cycle protein cyclin E. During osteogenic differentiation, PLC-β1 expression varies concomitantly with cyclin E expression and the two proteins interact. These findings contribute to clarify the pathways involved in osteogenic differentiation and provide evidence to develop therapeutic strategies for bone regeneration. Graphical abstract: