Scutebarbatolides A-C, new neo-clerodane diterpenoids from Scutellaria barbata D. Don with cytotoxic activity. (February 2019)

• Record Type: Journal Article
• Authors: Hanh, Tran Thi Hong; Anh, Do Hoang; Quang, Tran Hong; Trung, Nguyen Quang; Thao, Do Thi; Cuong, Nguyen The; An, Nguyen Thai; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Kiem, Phan Van; Minh, Chau Van
• Is Part Of: Phytochemistry letters. Volume 29(2019)
• Page Start: 65
• Page End: 69
• Publication Date: 2019-02
• Subjects: Scutellaria barbata -- Lamiaceae -- neo-Clerodane diterpenoid -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2018.11.008
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Nine neo -clerodane diterpenoids were isolated from Scutellaria barbata . Three new compounds namely scutebarbatolides A-C (1–3 ) were elucidated. Cytotoxicity toward five human cancer cell lines of the isolates was evaluated. Scutebarbatolide A (1 ) showed moderate cytotoxicity toward five tested cell lines. Abstract: Phytochemical investigation of the whole plant of Scutellaria barbata resulted in the isolation of three new neo -clerodane diterpenoids, named scutebarbatolides A-C (1–3 ), along with six known analogues as 14-deoxy-11, 12-didehydroandrographolide (4 ), scutehenanine H (5 ), 14β-hydroxyscutolide K (6 ), scutebata O (7 ), scutebartines H (8 ) and I (9 ). Their structures were elucidated by spectroscopic analyses, including 1D and 2D NMR and mass spectra in comparison with the data reported in the literature. Cytotoxicity of the isolates was evaluated toward five human cancer cell lines, including LNCaP, HepG2, KB, MCF7, and SK-Mel2 cells. Of the isolates, compounds1 and6 were shown to have moderate cytotoxicity toward all the cancer cell lines, with IC50 values ranging from 30.8 to 51.1 μM. Our results contribute to more insightful clarification of the use of S. barbata in the prevention and treatment of cancer.