The effect of an oral ginger supplementation on NF-κB concentration in peripheral blood mononuclear cells and anthropomorphic data of patients with type 2 diabetes: A randomized double-blind, placebo-controlled clinical trial. (February 2019)

• Record Type: Journal Article
• Authors: Mohammadzadeh Honarvar, Niyaz; Zarezadeh, Meysam; Khorshidi, Masoud; Makhdoomi Arzati, Motahareh; Yekaninejad, Mir Saeed; Abdollahi, Mina; Effatpanah, Mohammad; Hashemi, Rezvan; Saedisomeolia, Ahmad
• Is Part Of: Complementary therapies in medicine. Volume 42(2019)
• Page Start: 7
• Page End: 11
• Publication Date: 2019-02
• Subjects: Type 2 diabetes -- NF-kappa B -- Ginger -- Inflammation -- Clinical trial; Alternative medicine -- Periodicals; Complementary Therapies -- Periodicals; Médecines parallèles -- Périodiques; Thérapeutique -- Périodiques; Alternative medicine; Electronic journals; Periodicals; 615.5
• DOI: 10.1016/j.ctim.2018.10.019
• Languages: English
• ISSNs: 0965-2299

Abstract

Graphical abstract: Highlights: Ginger supplementation significantly decreased hip circumference, however, the amount was negligible. There was significant difference in dietary intake of poly unsaturated fatty acid, mono unsaturated fatty acid, vitamin E and vitamin C. There was no statistically significant effect of ginger supplementation on NF-κB concentrations in peripheral blood mononuclear cells. Abstract: Introduction: The complications of diabetes are extensive which can be caused by excessive oxidative stress, inflammation and impaired insulin system. Plant-sourced bioactive compounds can reduce inflammation and oxidative stress. The aim of present study was to determine the effect of ginger supplementation on diabetic complications. Methods: The present study is a randomized double blind clinical trial which is conducted with 48 diabetic patients. The participants were randomly divided into two intervention and placebo groups which were received 2 g ginger powder and 2 g wheat flour respectively for 10 weeks. Nuclear factor kappa B (NF-κB) concentration and anthropometric measurements were evaluated at the baseline and at the end of study. Results: The effect of ginger supplementation on hip circumference was marginal and there was no significant effect on BMI and waist circumference. Mean NF-κB p65 concentrations were reduced in ginger supplementation group, however, the amount was not statistically significant. Conclusion: Ginger supplementation had significant effects on anthropometric evaluations. Ginger supplementation decreased mean NF-κB concentration in comparison with placebo, however the significance level was marginal. In order to achieve reliable information, more researches should be complemented with uptake of other diagnostic tools.