Giant Condylomata Acuminata of Buschke-Lowenstein Associated With Paraneoplastic Hypercalcemia. (14th February 2018)

• Record Type: Journal Article
• Authors: Venter, Fredrick; Heidari, Arash; Viehweg, Macsen; Rivera, Mark; Natarajan, Piruthiviraj; Cobos, Everardo
• Is Part Of: Journal of investigative medicine high impact case reports. Volume 6(2018)
• Publication Date: 2018-02-14
• Subjects: giant condylomata acuminata -- Buschke Lowenstein tumor -- squamous cell carcinoma -- paraneoplastic hypercalcemia -- genital warts -- HPV vaccination -- E6 and E7 oncogenes -- human papillomavirus; Internal medicine -- Periodicals; Medical care -- Periodicals; 616.005
• DOI: 10.1177/2324709618758348
• Languages: English
• ISSNs: 2324-7096

Abstract

Low-risk human papillomavirus types 6 and 11 can manifest as giant condylomata acuminata (GCA) of Buschke-Lowenstein. Up to 50% of GCA can slowly progress over years to fungating, invasive tumors. The malignant potential is attributed to unique immune evading abilities of the human papillomavirus. A 42-year-old male presented with pain and foul-smelling discharge from his genital warts. The histopathological examination of the mass showed invasive squamous cell carcinoma, and it was associated with paraneoplastic hypercalcemia. The timely removal of long-standing GCA in order to prevent a carcinomatous transition is a priority.