Involvement of HGF/MET signaling in appendicular muscle development in cartilaginous fish. (15th January 2019)

• Record Type: Journal Article
• Authors: Okamoto, Eri; Moriyama, Yuuta; Kuraku, Shigehiro; Kai, Kei‐ichi; Tanaka, Mikiko
• Other Names: Tanaka M. guestEditor.
• Is Part Of: Development growth and differentiation. Volume 61:Number 1(2019)
• Page Start: 97
• Page End: 103
• Publication Date: 2019-01-15
• Subjects: appendicular muscles -- cartilaginous fish -- HGF/MET signaling; Embryology -- Periodicals; Developmental biology -- Periodicals; Growth -- Periodicals; 574.3
• DOI: 10.1111/dgd.12591
• Languages: English
• ISSNs: 0012-1592

Abstract

Abstract : In amniotes, limb muscle precursors de‐epithelialize from the ventral dermomyotome and individually migrate into limb buds. In catsharks, Scyliorhinus, fin muscle precursors are also derived from the ventral dermomyotome, but shortly after de‐epithelialization, they reaggregate within the pectoral fin bud and differentiate into fin muscles. Delamination of muscle precursors has been suggested to be controlled by hepatocyte growth factor (HGF) and its tyrosine kinase receptor (MET) in amniotes. Here, we explore the possibility that HGF/MET signaling regulates the delamination of appendicular muscle precursors in embryos of the catshark Scyliorhinus canicula . Our analysis reveals that Hgf is expressed in pectoral fin buds, whereas c‐Met expression in fin muscle precursors is rapidly downregulated. We propose that alteration of the duration of c‐Met expression in appendicular muscle precursors might underlie the evolution of individually migrating muscle precursors, which leads to the emergence of complex appendicular muscular systems in amniotes. Abstract : In catsharks, Hgf is expressed in pectoral fin buds, whereas c‐Met expression in fin muscle precursors is rapidly downregulated. We propose that alteration of the duration of c‐Met expression in appendicular muscle precursors might underlie the evolution of individually migrating muscle precursors, which leads to the emergence of complex appendicular muscular systems in amniotes.