Therapy‐related acute myeloid leukemia after chemotherapy in extensive disease‐small cell lung cancer. Issue 1 (19th November 2018)

• Record Type: Journal Article
• Authors: Ueda, Naoko; Fujita, Kohei; Okuno, Yoshiaki; Nakatani, Koichi; Mio, Tadashi
• Is Part Of: Clinical case reports. Volume 7:Issue 1(2019)
• Page Start: 100
• Page End: 103
• Publication Date: 2018-11-19
• Subjects: acute myeloid leukemia -- etoposide -- small cell lung cancer -- topoisomerase II inhibitors -- toxicity; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.1931
• Languages: English
• ISSNs: 2050-0904

Abstract

Key Clinical Message: We experienced therapy‐related acute myeloid leukemia (t‐AML) in a patient with extensive disease‐small cell lung cancer (ED‐SCLC). This case is rare and has educational message because ED‐SCLC has a poor prognosis and often cannot survive until developing therapy related hematological malignancy. Furthermore this case had unique chromosomal abnormalities. With recent advances in chemotherapy and radiotherapy, the prognosis of lung cancer has improved, while t‐AML has been increasing in frequency. Abstract : We experienced therapy‐related acute myeloid leukemia (t‐AML) in a patient with extensive disease‐small cell lung cancer (ED‐SCLC). This case is rare and has educational message because ED‐SCLC has a poor prognosis and often cannot survive until developing therapy related hematological malignancy. Furthermore this case had unique chromosomal abnormalities. With recent advances in chemotherapy and radiotherapy, the prognosis of lung cancer has improved, while t‐AML has been increasing in frequency.