Fluorescent Inorganic‐Organic Hybrid Nanoparticles. Issue 1 (19th October 2018)

• Record Type: Journal Article
• Authors: Neumeier, B. Lilli; Khorenko, Mikhail; Alves, Frauke; Goldmann, Oliver; Napp, Joanna; Schepers, Ute; Reichardt, Holger M.; Feldmann, Claus
• Is Part Of: ChemNanoMat. Volume 5:Issue 1(2019)
• Page Start: 24
• Page End: 45
• Publication Date: 2018-10-19
• Subjects: inorganic-organic hybrids -- phosphates -- sulfonates -- fluorescence -- imaging; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.201800310
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract: Inorganic‐organic hybrid nanoparticles (IOH‐NPs) with a general composition [ZrO] 2+ [RDye OPO3 ] 2−, [Ln] 3+ n/3 [RDye (SO3 )n ] n−, [Ln(OH)] 2+ n/2 [RDye (SO3 )n ] n−, or [LnO] + n [RDye (SO3 )n ] n− (Ln: lanthanide) are a novel class of nanomaterials for fluorescence detection and optical imaging. IOH‐NPs are characterized by an extremely high load of the fluorescent dye (70–85 wt‐%), high photochemical stability, straightforward aqueous synthesis, low material complexity, intense emission and high cell uptake at low toxicity. Besides full‐color emission, IOH‐NPs are suitable for multimodal imaging, singlet‐oxygen generation as well as drug delivery and drug release. This focus review presents the material concept of the IOH‐NPs as well as their synthesis and characterization. Their characteristic features are illustrated by selected in vitro and in vivo studies to initiate application in biology and medicine. Abstract : Extremely high dye contents (70–85 wt‐%) are available in inorganic‐organic hybrid nanoparticles (IOH‐NPs) such as [ZrO] 2+ [ RDye OPO3 ] 2− . They show intense emission, high photostability, high cell uptake at low toxicity, and they are also suitable for multimodal imaging, singlet‐oxygen generation and drug delivery.