Lost but not forgotten: A population‐based study of mortality and care trajectories among people living with HIV who are lost to follow‐up in Ontario, Canada. Issue 2 (26th November 2018)

• Record Type: Journal Article
• Authors: Kendall, CE; Raboud, J; Donelle, J; Loutfy, M; Rourke, SB; Kroch, A; Liddy, C; Rosenes, R; Burchell, AN
• Other Names: Cohen Jeffrey investigator.; Kilby Don investigator.; Crouzat Fred investigator.; Andany Nisha investigator.; Mittmann Nicole investigator.; Salit Irving investigator.; Silverman Michael investigator.; Sandre Roger investigator.
• Is Part Of: HIV medicine. Volume 20:Issue 2(2019)
• Page Start: 88
• Page End: 98
• Publication Date: 2018-11-26
• Subjects: cohort -- health services -- HIV -- lost to follow‐up -- mortality; HIV infections -- Treatment -- Periodicals; HIV-positive persons -- Periodicals; HIV infections -- Treatment -- Decision making -- Periodicals; 616.9792
• DOI: 10.1111/hiv.12682
• Languages: English
• ISSNs: 1464-2662

Abstract

Abstract : Objectives: Selection as a consequence of volunteer participation in, and loss to follow‐up from, cohort studies may bias estimates of mortality and other health outcomes. To quantify this potential, we estimated mortality and health service use among people living with HIV (PLWH) who were lost to cohort follow‐up (LTCFU) from a volunteer clinical HIV‐infected cohort, and compared these to mortality and health service use in active cohort participants and non‐cohort‐participants living with HIV in Ontario, Canada. Methods: We analysed population‐based provincial health databases from 1995 to 2014, identifying PLWH ≥ 18 years old; these included data from participants in the Ontario HIV Treatment Network Cohort Study (OCS), a volunteer, multi‐site clinical HIV‐infected cohort. We calculated all‐cause mortality, hospitalization and emergency department (ED) visit rates per 100 person‐years (PY) and estimated hazard ratios (HRs) of mortality, adjusting for age, sex, income, rurality, and immigration status. Results: Among 23 043 PLWH, 5568 were OCS participants. Compared with nonparticipants, participants were younger and less likely to be female, to be an immigrant and to reside in a major urban centre, and had lower comorbidity. Mortality among active participants, participants LTCFU and nonparticipants was 2.52, 3.30 and 2.20 per 100 PY, respectively. After adjustment for covariates, mortality risk was elevated among participants LTCFU compared with active participants (HR 2.26; 95% confidence interval 1.91, 2.68). Age‐adjusted hospitalization rates and ED visit rates were highest among participants LTCFU. Conclusions: Mortality risk and use of health care resources were lower among active cohort participants. Our findings may inform health outcome estimates based on volunteer cohorts, as well as quantitative bias adjustment to correct for such biases.