Understanding the Interaction of Glutamate Salts with Serum Albumin Protected Prism‐Shaped Silver Nanoparticles toward Glutamate Sensing. (21st August 2018)

• Record Type: Journal Article
• Authors: Zeng, Yuan; Chang, Yu‐Hsin; Gharib, Mustafa; Parak, Wolfgang J.; Chakraborty, Indranath
• Is Part Of: Particle and particle systems characterization. Volume 36:Number 1(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-21
• Subjects: bovine serum albumin -- glutamates -- nanoparticles -- prisms -- sensing; Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201800229
• Languages: English
• ISSNs: 0934-0866

Abstract

Abstract: Surface plasmon spectroscopy of serum albumin protected prism‐shaped silver nanoparticles is used as simple and effective sensing tool to detect glutamate salts. The approach does not require any electrochemical setup to detect glutamates, in contrast to common techniques to detect glutamates in general. Experiments reveal that upon presence of high concentrations of glutamate salts, the prism‐shaped nanoparticles are transformed to smaller‐sized nanoclusters, while the remaining nanoparticles are assembled to form aggregates. Control experiments confirm that the interaction is specific to the serum albumin coating, the prism shape of the nanoparticles, and to silver. Abstract : Serum albumin protected prism‐shaped silver nanoparticles (NPs) are used for detection of glutamate salts using surface plasmon resonance (SPR) spectroscopy as sensing tool. Among the different biological molecules, glutamate salts induce a pronounced change in the SPR of the Ag NPs and underlying mechanisms of such specific interaction are examined in details.