A first case of hepatocellular carcinoma in the baboon (Papio spp.) placenta. Issue 1 (24th September 2018)

• Record Type: Journal Article
• Authors: Schlabritz‐Loutsevitch, Natalia; Carrillo, Maira; Li, Cun; Nathanielsz, Peter; Maguire, Christopher; Maher, James; Dick, Edward; Hubbard, Gene; Stanek, Jerzy
• Is Part Of: Journal of medical primatology. Volume 48:Issue 1(2019)
• Page Start: 68
• Page End: 73
• Publication Date: 2018-09-24
• Subjects: baboon -- hepatocellular carcinoma -- non‐human primates -- placenta; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12382
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: We present a case of hepatocellular carcinoma (HCC) in the placenta of healthy baboon ( Papio spp .). Grossly, the fetal, maternal, and placental tissues were unremarkable. Histologically, the placenta contained an unencapsulated, poorly demarcated, infiltrative, solidly cellular neoplasm composed of cells that resembled hepatocytes. The neoplastic cells were diffusely positive for vimentin and focally positive for Ae1/Ae3, Arginase ‐1, glutamine synthetase, and CD10, and negative for ER, vascular markers (CD31 and D240), S100, glypican, C‐reactive protein, FABP, desmin, and beta‐catenin; INI1 positivity was similar to non‐neoplastic tissues. The case likely represents a unique subtype of HCC.