Mobile Microrobots for Active Therapeutic Delivery. Issue 1 (10th October 2018)

• Record Type: Journal Article
• Authors: Erkoc, Pelin; Yasa, Immihan C.; Ceylan, Hakan; Yasa, Oncay; Alapan, Yunus; Sitti, Metin
• Is Part Of: Advanced therapeutics. Volume 2:Issue 1(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-10-10
• Subjects: active therapeutic delivery -- cell‐mediated delivery -- drug delivery -- microrobot -- single cell manipulation; Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.201800064
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract: Recent advances in the versatility and sophistication of design, fabrication, and control methods of mobile microrobots could have a transforming impact on future healthcare technologies. Self‐propelled or remotely actuated, synthetic, or biohybrid microrobots can navigate to difficult‐to‐reach regions in the human body to deliver therapeutics for microscopically localized medical interventions. Here, recent progress in the design of microrobotic systems concerning therapeutic delivery of drugs, cells, and genetic materials is reported. This perspective prioritizes the design aspects of microrobots for medical cargo loading, navigation in biologically relevant environments, and controlled cargo release. In the final section, future prospects and a discussion on the critical shortcomings for the benchside‐to‐bedside translation of medical microrobots are provided. Abstract : Microrobots are emerging as a new generation of active drug‐delivery platforms . These active drug‐delivery platforms, fabricated from synthetic and biohybrid materials, can navigate by self‐propulsion or external guidance and locally deliver therapeutics in hard‐to‐reach, confined body regions. This report focuses on recent microrobotic strategies from a therapeutic delivery perspective while addressing the limitations and potential toward future clinical applications.