Electrophysiology as a theoretical and methodological hub for the neural sciences. (16th December 2018)

• Record Type: Journal Article
• Authors: Cavanagh, James F.
• Is Part Of: Psychophysiology. Volume 56:Number 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-16
• Subjects: computational modeling -- EEG -- ERPs -- neurology -- psychiatry -- translation; Psychophysiology -- Periodicals; 612.8
• DOI: 10.1111/psyp.13314
• Languages: English
• ISSNs: 0048-5772

Abstract

Abstract: Electrophysiology is a direct measure of neuronal processes, and it is uniquely sensitive to canonical neural operations that underlie emergent psychological operations. These qualities make it well suited for discovery of aberrant neural mechanisms that underlie complicated disease states. This technique is routinely utilized in vitro, in vivo, and in outpatient neurological clinics, offering a translatable bridge between animal models and human patients. The bench‐to‐bedside potential of this approach is unparalleled, yet it also remains undeveloped due to the slow inertia of legacy techniques and interpretations. In this review, I discuss these strengths of the method, and I detail compelling reasons why future advancements can have a direct and tangible influence over clinical practice. I hope to motivate a blurring of traditional boundaries between preclinical, computational, imaging, and clinical fields by advancing electrophysiology as a common hub for methodological integration and theoretical advancement. Abstract : Electrophysiology is a direct measure of neuronal processes, and it is uniquely sensitive to canonical neural operations that underlie emergent psychological operations. This measure is routinely utilized in vitro, in vivo, and in outpatient neurological clinics, offering a translatable bridge between animal models and human patients. The aim of this theoretical review is to motivate an increased utilization of electrophysiology in the understanding of neural coding, the translation of findings across species, and for diagnosis and prognosis in clinical practice.