Sex‐related differences in left ventricular diastolic function and arterial elastance during admission in patients with heart failure with preserved ejection fraction: The PURSUIT HFpEF study. Issue 12 (22nd November 2018)

• Record Type: Journal Article
• Authors: Hoshida, Shiro; Watanabe, Tetsuya; Shinoda, Yukinori; Ikeoka, Kuniyasu; Minamisaka, Tomoko; Fukuoka, Hidetada; Inui, Hirooki; Ueno, Keisuke; Suna, Shinichiro; Nakatani, Daisaku; Hikoso, Shungo; Yamada, Takahisa; Yasumura, Yoshio; Fuji, Hisakazu; Sakata, Yasushi
• Other Names: Tamaki Shunsuke investigator.; Fukunami Masatake investigator.; Yamada Takahisa investigator.; Hayashi Takaharu investigator.; Takeda Yasuharu investigator.; Higuchi Yoshiharu investigator.; Masuda Masaharu investigator.; Asai Mitsutoshi investigator.; Mano Toshiaki investigator.; Fuji Hisakazu investigator.; Takeda Yoshihiro investigator.; Takeda Yoshihiro investigator.; Nagai Yoshiyuki investigator.; Yamashita Shizuya investigator.; Nakagawa Yusuke investigator.; Nozaki Shuichi investigator.; Abe Haruhiko investigator.; Ueda Yasunori investigator.; Uematsu Masaaki investigator.; Koretsune Yukihiro investigator.; Nagai Kunihiko investigator.; Yano Masamichi investigator.; Nishino Masami investigator.; Tanouchi Jun investigator.; Segawa Takatsugu investigator.; Hasegawa Shinji investigator.; Yoshima Syouhei investigator.; Ichikawa Minoru investigator.; Kijima Yoshiyuki investigator.; Rin Eisai investigator.; Watanabe Tetsuya investigator.; Hoshida Shiro investigator.; Izumi Masahiro investigator.; Yamamoto Hiroyoshi investigator.; Kato Hiroyasu investigator.; Nakatani Kazuhiro investigator.; Hiraoka Hisatoyo investigator.; Hirooka Keiji investigator.; Nishio Mayu investigator.; Yoshimura Takahiro investigator.; Okuyama Yuji investigator.; Sasaki Tatsuya investigator.; Tani Akihiro investigator.; Okumoto Yasushi investigator.; Akagi Hideharu investigator.; Makino Yasunaka investigator.; Iwakura Katsuomi investigator.; Takano Yuzuru investigator.; Nishikawa Nagahiro investigator.; Kitao Takashi investigator.; Kanai Hideyuki investigator.; Shioyama Wataru investigator.; Mukai Mikio investigator.; Fujita Masashi investigator.; Harada Koichiro investigator.; Nakagawa Osamu investigator.; Araki Ryo investigator.; Yamada Takayuki investigator.; Yasumura Yoshio investigator.; Sera Fusako investigator.; Nakamoto Kei investigator.; Tsukamoto Yasumasa investigator.; Toshinari Onishi investigator.; Kioka Hidetaka investigator.; Ohtani Tomohito investigator.; Mizuno Hiroya investigator.; Kojima Takayuki investigator.; Dohi Tomoharu investigator.; Suna Shinichiro investigator.; Hikoso Shungo investigator.; Nakatani Daisaku investigator.; Takeda Toshihiro investigator.; Nakagawa Akito investigator.; Matsumura Yasushi investigator.; Sakata Yasushi investigator.;
• Is Part Of: Clinical cardiology. Volume 41:Issue 12(2018)
• Page Start: 1529
• Page End: 1536
• Publication Date: 2018-11-22
• Subjects: arterial elastance -- diastolic function -- elderly -- left cardiac volume -- sex; Cardiology -- Periodicals; 616.12005
• DOI: 10.1002/clc.23073
• Languages: English
• ISSNs: 0160-9289

Abstract

Abstract : Background: We previously reported that an index of afterload‐related left ventricular diastolic function, operant diastolic elastance (Ed)/effective arterial elastance (Ea) = E/e'/(0.9 × systolic blood pressure), was significantly higher in elderly hypertensive women. We aimed to determine sex‐related differences in the E/e'‐related indices for left ventricular diastolic function and their related factors during admission in patients with heart failure with preserved ejection fraction (HFpEF). Hypothesis: Elderly HFpEF women exhibit severe left ventricular diastolic dysfunction associated with different left atrioventricular volume ratio. Methods: We divided 267 patients with HFpEF (men/women, 116/151) into two groups by age (≥75 years, n = 212; <75 years, n = 55). We examined the alterations of E/e', E/e'/stroke volume index = Ed, and Ed/Ea, and cardiac structure during admission. Results: Ed and Ea were significantly higher in women than in men, at admission, especially in patients ≥75 years. Before discharge, not only Ed and Ea but also Ed/Ea was significantly higher in women than in men, especially in patients ≥75 years. Elderly female patients had larger left atrial than left ventricular volume. Conclusions: Higher afterload‐related left ventricular diastolic elastance, Ed/Ea, in association with higher arterial elastance, Ea, accompanied by left atrioventricular volume mismatch was observed in elderly HFpEF women.