Curvulin and spirostaphylotrichins R and U from extracts produced by two endophytic Bipolaris sp. associated to aquatic macrophytes with antileishmanial activity. Issue 23 (2nd December 2018)

• Record Type: Journal Article
• Authors: de Almeida, Tiago Tognolli; Ribeiro, Marcos Alessandro dos Santos; Polonio, Julio Cesar; Garcia, Francielle Pelegrin; Nakamura, Celso Vataru; Meurer, Eduardo Cesar; Sarragiotto, Maria Helena; Baldoqui, Débora Cristina; Azevedo, João Lúcio; Pamphile, João Alencar
• Is Part Of: Natural product research. Volume 32:Issue 23(2018)
• Page Start: 2783
• Page End: 2790
• Publication Date: 2018-12-02
• Subjects: Eichhornia azurea -- Eichhornia crassipes -- endophytes -- MS/MS fragmentation mechanism;; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1380011
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In the present study, biological activity and chemical composition of two crude extracts of endophytic fungal strains of Bipolaris genera isolated from two species of aquatic macrophytes: Eichhornia azurea (Kunth) and Eichhornia crassipes (Mart.) were investigated. The nuclear magnetic resonance and mass spectrometry data provided the identification of three main compounds: curvulin (1 ), spirostaphylotrichin R (2 ) and U (3 ). The fragmentation mechanism of the precursor ions towards collision induced dissociation (CID) tandem mass spectrometry experiment (MS/MS) is also proposed. Furthermore, biological screening of the crude extracts displayed antileishmanial activity with IC50 values ranging from 70–84.2 μg.mL −1 . Abstract :