A case of TAFRO syndrome, a variant of multicentric Castleman's disease, successfully treated with corticosteroid and cyclosporine A. Issue 1 (2nd January 2019)

• Record Type: Journal Article
• Authors: Takasawa, Naruhiko; Sekiguchi, Yukio; Takahashi, Tsuneyuki; Muryoi, Akira; Satoh, Jo; Sasaki, Takeshi
• Is Part Of: Modern rheumatology. Volume 29:Issue 1(2019)
• Page Start: 198
• Page End: 202
• Publication Date: 2019-01-02
• Subjects: Corticosteroid -- Cyclosporine A -- Multicentric Castleman's disease -- TAFRO syndrome; Rheumatology -- Periodicals; 616.723005
• DOI: 10.1080/14397595.2016.1206243
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract: We report a case of a 46-year-old woman with fever, pleural effusion, massive ascites, severe edema, hepatosplenomegaly, elevation of serum creatinine level, proteinuria, and severe thrombocytopenia. Her clinical features were compatible with TAFRO syndrome proposed as a variant of multicentric Castleman's disease, that is occasionally associated with poor prognosis. Treatment with corticosteroid improved her symptoms partially. However, thrombocytopenia, ascites, and edema persisted. The use of cyclosporine A successfully improved her condition, resulting in remission.