One-pot three-component synthesis of 1, 4, 5-trisubstituted 5-iodo-1, 2, 3-triazoles from 1-copper(i) alkyne, azide and molecular iodine. Issue 19 (29th January 2015)

• Record Type: Journal Article
• Authors: Zhang, Jianlan; Chen, Wenwen; Wang, Bo; Zhao, Zhouxing; Wang, Xinyan; Hu, Yuefei
• Is Part Of: RSC advances. Volume 5:Issue 19(2015)
• Page Start: 14561
• Page End: 14566
• Publication Date: 2015-01-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c4ra15980b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The desired 5-iodo-1, 2, 3-triazoles were synthesized conveniently without using the pre-made 1-iodoalkynes as substrates. Abstract : Copper(i )-catalyzed cycloaddition of 1-iodoalkyne and azide has proven to be the most efficient method for the synthesis of 1, 4, 5-trisubstituted 5-iodo-1, 2, 3-triazoles, but pre-made 1-iodoalkyne is required. We find that the combination of 1-copper(i ) alkyne and molecular iodine can serve as a synthetic equivalent of 1-iodoalkyne. Thus, the desired 5-iodo-1, 2, 3-triazole can be synthesized by simply mixing this combination and an azide together without the tedious synthesis of the corresponding 1-iodoalkyne.