Serum vitamin E as a significant prognostic factor in patients with dyslipidemia disorders. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Barzegar-Amini, Maral; Ghazizadeh, Hamideh; Seyedi, Seyed Mohammad reza; Sadeghnia, Hamid Reza; Mohammadi, Akram; Hassanzade-Daloee, Mahdi; Barati, Elham; kharazmi-Khorassani, Sara; kharazmi-Khorassani, jasmin; Mohammadi-Bajgiran, Maryam; Tavallaie, Shima; Ferns, Gordon A.; Mouhebati, Mohsen; Ebrahimi, Mahmoud; Tayefi, Maryam; Ghayour-Mobarhan, Majid
• Is Part Of: Diabetes & metabolic syndrome. Volume 13:Issue 1(2019)
• Page Start: 666
• Page End: 671
• Publication Date: 2019-01
• Subjects: Serum vitamin E -- Dyslipidemia disorders -- Prognostic and therapeutic factor -- Lipid profile -- Anthropometric parameters; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2018.11.034
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Objectives: Obesity and overweight are among the main causes of cardiovascular disease (CVD) mortality. Dyslipidemia, fatty liver index, is strongly related to CVD. Vitamin E as an antioxidant protects the hepatic cells against oxidative stress and prevents fatty liver disease. The aim of the current study is to evaluate the relationship between anthropometric parameters and fasted lipid profile with serum vitamin E levels. Study design: A randomized trial was designed based on data from the Mashhad stroke and heart atherosclerotic disorders (MASHAD: 2010–2020). Methods: 363 CVD subjects (173 males and 190 females) was selected at random, among 9704 subjects in three regions of Mashhad, northeast of Iran to investigate the specific correlations among their serum vitamin E, lipid profile (TG, HDL-C, LDL-C and TC), and anthropometric features (height, weight, BMI, hip and waist circumferences. Result: The results indicated the significant relationships between vitamin E, and fasting serum lipid profile in subjects. Serum vitamin E was negatively correlated to TC, TG, and LDL-C and positively related to HDL-C. Also, statistically negative correlations were found between vitamin E and anthropometric parameters (weight, waist and hip circumference, middle Arm, and Systolic Blood Pressure). Moreover, vitamin E ratios such as vitamin E/(TC + TG) and vitamin E/TC values as standardized vitamin E, had significant negative correlation with BMI, the whole of anthropometric parameters, and dyslipidemia risk factors including TC, TG and LDL-C. Conclusion: We found that vitamin E profile was significantly lower in the dyslipidemia subjects. It is generally suggested that vitamin E monitoring might be used as a useful prognostic and therapeutic agent in dyslipidemia disorder.