Acquisition of antimicrobial-resistant variants in repeated infections caused by Pseudomonas aeruginosa revealed by whole genome sequencing. Issue 2 (February 2019)

• Record Type: Journal Article
• Authors: Nakanishi, Noriko; Nomoto, Ryohei; Sato, Kanako; Koike, Chihiro; Kusuki, Mari; Nakamura, Tatsuya; Shigemura, Katsumi; Shirakawa, Toshiro; Fujisawa, Masato; Tokimatsu, Issei; Osawa, Kayo
• Is Part Of: Journal of infection and chemotherapy. Volume 25:Issue 2(2019:Feb.)
• Page Start: 154
• Page End: 156
• Publication Date: 2019-02
• Subjects: Pseudomonas aeruginosa -- Antibiotic resistance -- WGS -- SNP -- mexR; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2018.07.016
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: Pseudomonas aeruginosa, responsible for serious nosocomial-acquired infections, possesses intrinsic antibiotic resistance mechanisms and commonly exhibits multidrug resistance. Here, we report the evolving resistance profiles of strains isolated from the sputum of a patient being treated for repeated P. aeruginosa infections following cancer resection. Whole genome sequencing of six isolates obtained over a 2-month period revealed two key single nucleotide polymorphisms in the mexR and gyrB genes that affected efflux pump expression and antimicrobial resistance.